Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study.
Identifieur interne : 000328 ( Main/Exploration ); précédent : 000327; suivant : 000329Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study.
Auteurs : Alberto Alonso-Fernández [Espagne] ; Nuria Toledo-Pons [Espagne] ; Borja G. Cosío [Espagne] ; Aina Millán [Espagne] ; Néstor Calvo [Espagne] ; Luisa Ram N [Espagne] ; Sara Hermoso De Mendoza [Espagne] ; Daniel Morell-García [Espagne] ; Josep Miquel Bauça-Rossello [Espagne] ; Belén Nú Ez [Espagne] ; Jaume Pons [Espagne] ; Juan A. Palmer [Espagne] ; Luisa Martín [Espagne] ; María Pe Aranda [Espagne] ; Joan A. Pou [Espagne] ; Jaume Sauleda [Espagne] ; Ernest Sala-Llinas [Espagne]Source :
- PloS one [ 1932-6203 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Angiographie par tomodensitométrie (MeSH), Betacoronavirus (MeSH), Embolie pulmonaire (diagnostic), Embolie pulmonaire (virologie), Espagne (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (complications), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Produits de dégradation de la fibrine et du fibrinogène (analyse), Prévalence (MeSH), Sujet âgé (MeSH), Études prospectives (MeSH).
- MESH :
- analyse : Produits de dégradation de la fibrine et du fibrinogène.
- diagnostic : Embolie pulmonaire.
- virologie : Embolie pulmonaire.
- Adulte d'âge moyen, Angiographie par tomodensitométrie, Betacoronavirus, Espagne, Femelle, Humains, Infections à coronavirus, Mâle, Pandémies, Pneumopathie virale, Prévalence, Sujet âgé, Études prospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Aged (MeSH), Betacoronavirus (MeSH), Computed Tomography Angiography (MeSH), Coronavirus Infections (complications), Female (MeSH), Fibrin Fibrinogen Degradation Products (analysis), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Prevalence (MeSH), Prospective Studies (MeSH), Pulmonary Embolism (diagnosis), Pulmonary Embolism (virology), Spain (MeSH).
- MESH :
- chemical , analysis : Fibrin Fibrinogen Degradation Products.
- geographic : Spain.
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Pulmonary Embolism.
- virology : Pulmonary Embolism.
- Aged, Betacoronavirus, Computed Tomography Angiography, Female, Humans, Male, Middle Aged, Pandemics, Prevalence, Prospective Studies.
Abstract
INTRODUCTION
Coronavirus disease 2019 (COVID-19) pneumonia is associated to systemic hyper-inflammation and abnormal coagulation profile. D-dimer elevation is particularly frequent, and values higher than 1μg/mL have been associated with disease severity and in-hospital mortality. Previous retrospective studies found a high pulmonary embolism (PE) prevalence, however, it should be highlighted that diagnoses were only completed when PE was clinically suspected.
MATERIAL AND METHODS
Single-center prospective cohort study. Between April 6th and April 17th 2020, consecutive confirmed cases of COVID-19 pneumonia with D-dimer >1 μg/mL underwent computed tomography pulmonary angiography (CTPA) to investigate the presence and magnitude of PE. Demographic and laboratory data, comorbidities, CTPA scores, administered treatments, and, clinical outcomes were analysed and compared between patients with and without PE.
RESULTS
Thirty consecutive patients (11 women) were included. PE was diagnosed in 15 patients (50%). In patients with PE, emboli were located mainly in segmental arteries (86%) and bilaterally (60%). Patients with PE were significantly older (median age 67.0 (IQR 63.0-73.0) vs. 57.0 (IQR 48.0-69.0) years, p = .048) and did not differ in sex or risk factors for thromboembolic disease from the non-PE group. D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. D-dimer values correlated with the radiologic magnitude of PE (p<0.001).
CONCLUSIONS
Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. We consider that these findings could contribute to improve the prognosis of patients with COVID-19 pneumonia, by initiating anticoagulant therapy when a PE is found.
DOI: 10.1371/journal.pone.0238216
PubMed: 32841275
PubMed Central: PMC7447036
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Millan, Aina" sort="Millan, Aina" uniqKey="Millan A" first="Aina" last="Millán">Aina Millán</name><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Calvo, Nestor" sort="Calvo, Nestor" uniqKey="Calvo N" first="Néstor" last="Calvo">Néstor Calvo</name><affiliation wicri:level="1"><nlm:affiliation>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Ram N, Luisa" sort="Ram N, Luisa" uniqKey="Ram N L" first="Luisa" last="Ram N">Luisa Ram N</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="De Mendoza, Sara Hermoso" sort="De Mendoza, Sara Hermoso" uniqKey="De Mendoza S" first="Sara Hermoso" last="De Mendoza">Sara Hermoso De Mendoza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Morell Garcia, Daniel" sort="Morell Garcia, Daniel" uniqKey="Morell Garcia D" first="Daniel" last="Morell-García">Daniel Morell-García</name><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Bauca Rossello, Josep Miquel" sort="Bauca Rossello, Josep Miquel" uniqKey="Bauca Rossello J" first="Josep Miquel" last="Bauça-Rossello">Josep Miquel Bauça-Rossello</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Nu Ez, Belen" sort="Nu Ez, Belen" uniqKey="Nu Ez B" first="Belén" last="Nú Ez">Belén Nú Ez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Pons, Jaume" sort="Pons, Jaume" uniqKey="Pons J" first="Jaume" last="Pons">Jaume Pons</name><affiliation wicri:level="1"><nlm:affiliation>Cardiology Department, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cardiology Department, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, Juan A" sort="Palmer, Juan A" uniqKey="Palmer J" first="Juan A" last="Palmer">Juan A. Palmer</name><affiliation wicri:level="1"><nlm:affiliation>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Luisa" sort="Martin, Luisa" uniqKey="Martin L" first="Luisa" last="Martín">Luisa Martín</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Pe Aranda, Maria" sort="Pe Aranda, Maria" uniqKey="Pe Aranda M" first="María" last="Pe Aranda">María Pe Aranda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Pou, Joan A" sort="Pou, Joan A" uniqKey="Pou J" first="Joan A" last="Pou">Joan A. Pou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Sauleda, Jaume" sort="Sauleda, Jaume" uniqKey="Sauleda J" first="Jaume" last="Sauleda">Jaume Sauleda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Enfermedades Respiratorias, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Sala Llinas, Ernest" sort="Sala Llinas, Ernest" uniqKey="Sala Llinas E" first="Ernest" last="Sala-Llinas">Ernest Sala-Llinas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Enfermedades Respiratorias, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32841275</idno><idno type="pmid">32841275</idno><idno type="doi">10.1371/journal.pone.0238216</idno><idno type="pmc">PMC7447036</idno><idno type="wicri:Area/Main/Corpus">000500</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000500</idno><idno type="wicri:Area/Main/Curation">000500</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000500</idno><idno type="wicri:Area/Main/Exploration">000500</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study.</title><author><name sortKey="Alonso Fernandez, Alberto" sort="Alonso Fernandez, Alberto" uniqKey="Alonso Fernandez A" first="Alberto" last="Alonso-Fernández">Alberto Alonso-Fernández</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Enfermedades Respiratorias, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Toledo Pons, Nuria" sort="Toledo Pons, Nuria" uniqKey="Toledo Pons N" first="Nuria" last="Toledo-Pons">Nuria Toledo-Pons</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Cosio, Borja G" sort="Cosio, Borja G" uniqKey="Cosio B" first="Borja G" last="Cosío">Borja G. Cosío</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Enfermedades Respiratorias, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Millan, Aina" sort="Millan, Aina" uniqKey="Millan A" first="Aina" last="Millán">Aina Millán</name><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Calvo, Nestor" sort="Calvo, Nestor" uniqKey="Calvo N" first="Néstor" last="Calvo">Néstor Calvo</name><affiliation wicri:level="1"><nlm:affiliation>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Ram N, Luisa" sort="Ram N, Luisa" uniqKey="Ram N L" first="Luisa" last="Ram N">Luisa Ram N</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="De Mendoza, Sara Hermoso" sort="De Mendoza, Sara Hermoso" uniqKey="De Mendoza S" first="Sara Hermoso" last="De Mendoza">Sara Hermoso De Mendoza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Morell Garcia, Daniel" sort="Morell Garcia, Daniel" uniqKey="Morell Garcia D" first="Daniel" last="Morell-García">Daniel Morell-García</name><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Bauca Rossello, Josep Miquel" sort="Bauca Rossello, Josep Miquel" uniqKey="Bauca Rossello J" first="Josep Miquel" last="Bauça-Rossello">Josep Miquel Bauça-Rossello</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Nu Ez, Belen" sort="Nu Ez, Belen" uniqKey="Nu Ez B" first="Belén" last="Nú Ez">Belén Nú Ez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Pons, Jaume" sort="Pons, Jaume" uniqKey="Pons J" first="Jaume" last="Pons">Jaume Pons</name><affiliation wicri:level="1"><nlm:affiliation>Cardiology Department, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cardiology Department, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, Juan A" sort="Palmer, Juan A" uniqKey="Palmer J" first="Juan A" last="Palmer">Juan A. Palmer</name><affiliation wicri:level="1"><nlm:affiliation>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Luisa" sort="Martin, Luisa" uniqKey="Martin L" first="Luisa" last="Martín">Luisa Martín</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Pe Aranda, Maria" sort="Pe Aranda, Maria" uniqKey="Pe Aranda M" first="María" last="Pe Aranda">María Pe Aranda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Pou, Joan A" sort="Pou, Joan A" uniqKey="Pou J" first="Joan A" last="Pou">Joan A. Pou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Sauleda, Jaume" sort="Sauleda, Jaume" uniqKey="Sauleda J" first="Jaume" last="Sauleda">Jaume Sauleda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Enfermedades Respiratorias, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author><author><name sortKey="Sala Llinas, Ernest" sort="Sala Llinas, Ernest" uniqKey="Sala Llinas E" first="Ernest" last="Sala-Llinas">Ernest Sala-Llinas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Enfermedades Respiratorias, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Computed Tomography Angiography (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Female (MeSH)</term><term>Fibrin Fibrinogen Degradation Products (analysis)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Prevalence (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Pulmonary Embolism (diagnosis)</term><term>Pulmonary Embolism (virology)</term><term>Spain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Angiographie par tomodensitométrie (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Embolie pulmonaire (diagnostic)</term><term>Embolie pulmonaire (virologie)</term><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Produits de dégradation de la fibrine et du fibrinogène (analyse)</term><term>Prévalence (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Produits de dégradation de la fibrine et du fibrinogène</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pulmonary Embolism</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Embolie pulmonaire</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Embolie pulmonaire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pulmonary Embolism</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Computed Tomography Angiography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prevalence</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Angiographie par tomodensitométrie</term><term>Betacoronavirus</term><term>Espagne</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Prévalence</term><term>Sujet âgé</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Coronavirus disease 2019 (COVID-19) pneumonia is associated to systemic hyper-inflammation and abnormal coagulation profile. D-dimer elevation is particularly frequent, and values higher than 1μg/mL have been associated with disease severity and in-hospital mortality. Previous retrospective studies found a high pulmonary embolism (PE) prevalence, however, it should be highlighted that diagnoses were only completed when PE was clinically suspected.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIAL AND METHODS</b></p><p>Single-center prospective cohort study. Between April 6th and April 17th 2020, consecutive confirmed cases of COVID-19 pneumonia with D-dimer >1 μg/mL underwent computed tomography pulmonary angiography (CTPA) to investigate the presence and magnitude of PE. Demographic and laboratory data, comorbidities, CTPA scores, administered treatments, and, clinical outcomes were analysed and compared between patients with and without PE.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Thirty consecutive patients (11 women) were included. PE was diagnosed in 15 patients (50%). In patients with PE, emboli were located mainly in segmental arteries (86%) and bilaterally (60%). Patients with PE were significantly older (median age 67.0 (IQR 63.0-73.0) vs. 57.0 (IQR 48.0-69.0) years, p = .048) and did not differ in sex or risk factors for thromboembolic disease from the non-PE group. D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. D-dimer values correlated with the radiologic magnitude of PE (p<0.001).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. We consider that these findings could contribute to improve the prognosis of patients with COVID-19 pneumonia, by initiating anticoagulant therapy when a PE is found.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32841275</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>04</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>8</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study.</ArticleTitle><Pagination><MedlinePgn>e0238216</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0238216</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Coronavirus disease 2019 (COVID-19) pneumonia is associated to systemic hyper-inflammation and abnormal coagulation profile. D-dimer elevation is particularly frequent, and values higher than 1μg/mL have been associated with disease severity and in-hospital mortality. Previous retrospective studies found a high pulmonary embolism (PE) prevalence, however, it should be highlighted that diagnoses were only completed when PE was clinically suspected.</AbstractText><AbstractText Label="MATERIAL AND METHODS">Single-center prospective cohort study. Between April 6th and April 17th 2020, consecutive confirmed cases of COVID-19 pneumonia with D-dimer >1 μg/mL underwent computed tomography pulmonary angiography (CTPA) to investigate the presence and magnitude of PE. Demographic and laboratory data, comorbidities, CTPA scores, administered treatments, and, clinical outcomes were analysed and compared between patients with and without PE.</AbstractText><AbstractText Label="RESULTS">Thirty consecutive patients (11 women) were included. PE was diagnosed in 15 patients (50%). In patients with PE, emboli were located mainly in segmental arteries (86%) and bilaterally (60%). Patients with PE were significantly older (median age 67.0 (IQR 63.0-73.0) vs. 57.0 (IQR 48.0-69.0) years, p = .048) and did not differ in sex or risk factors for thromboembolic disease from the non-PE group. D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. D-dimer values correlated with the radiologic magnitude of PE (p<0.001).</AbstractText><AbstractText Label="CONCLUSIONS">Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. We consider that these findings could contribute to improve the prognosis of patients with COVID-19 pneumonia, by initiating anticoagulant therapy when a PE is found.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alonso-Fernández</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-0802-8871</Identifier><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toledo-Pons</LastName><ForeName>Nuria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cosío</LastName><ForeName>Borja G</ForeName><Initials>BG</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Millán</LastName><ForeName>Aina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Néstor</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramón</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Mendoza</LastName><ForeName>Sara Hermoso</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morell-García</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauça-Rossello</LastName><ForeName>Josep Miquel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Núñez</LastName><ForeName>Belén</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pons</LastName><ForeName>Jaume</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cardiology Department, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palmer</LastName><ForeName>Juan A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Radiodiagnostic Department, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peñaranda</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pou</LastName><ForeName>Joan A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sauleda</LastName><ForeName>Jaume</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sala-Llinas</LastName><ForeName>Ernest</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Enfermedades Respiratorias, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut d'Investigació Sanitària Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005338">Fibrin Fibrinogen Degradation Products</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C036309">fibrin fragment D</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072226" MajorTopicYN="N">Computed Tomography Angiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005338" MajorTopicYN="N">Fibrin Fibrinogen Degradation Products</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011655" MajorTopicYN="N">Pulmonary Embolism</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32841275</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0238216</ArticleId><ArticleId IdType="pii">PONE-D-20-17044</ArticleId><ArticleId IdType="pmc">PMC7447036</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Semin Thromb Hemost. 2020 May 12;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32396963</ArticleId></ArticleIdList></Reference><Reference><Citation>Thromb Res. 2020 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